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Sildenafil citrate, commonly known by the brand name, is a prescription-only medicine used to treat erectile dysfunction (ED) in adult men. It works by improving blood flow to the penis, helping to achieve and maintain an erection during sexual activity.

Dosage and Administration

Sildenafil is available in 25mg, 50mg, and 100mg strengths.

  • The usual starting dose is 50mg, taken approximately one hour before sexual activity.
  • Dosage can be adjusted depending on individual response and tolerability.
  • Take only one tablet in 24 hours, with or without food.
  • Avoid grapefruit juice, as it can increase the risk of side effects.
  • A high-fat meal may delay onset of action.

Effectiveness

Sildenafil has been shown to be effective in up to 80% of men with ED, with effects typically noticeable within 30 to 60 minutes, and lasting for up to 4–5 hours.

Side Effects

Common side effects include:

  • Headache
  • Flushing
  • Nasal congestion
  • Indigestion

Less common but serious effects include visual disturbances, hearing changes, or prolonged erections. Seek medical attention if severe or persistent side effects occur.

Contraindications

Sildenafil should not be used by those:

  • Taking nitrates for chest pain
  • With severe heart or liver conditions
  • Under 18 years of age
  • With certain medication interactions (e.g. alpha-blockers, antifungals, antibiotics)

Interactions

Inform your doctor of all medications and supplements before use. Interactions may occur with:

  • Nitrates
  • Alpha-blockers
  • Some antibiotics and antifungal medicines

Alcohol and Heart Conditions

Avoid excessive alcohol while taking sildenafil, as it can lower blood pressure and increase side effect risk. Use with caution if you have any heart-related conditions.

Availability and Cost

Sildenafil is available by prescription only in the UK.

  • Generic versions are more affordable than branded Viagra.
  • Supplied by licensed UK pharmacies such as Online Chemist.
  • Avoid counterfeit products from unregulated websites.

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Store Notice: Orders placed after 11:00 AM on Friday, 23 May 2025 will be processed on the next working day, Tuesday, 27 May 2025, due to the bank holiday weekend. Thank you for your understanding.

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    N interchangeably: 'alli - the medical term for a patient’s information,' or 'alli' for short.

    Sildenafil citrate, commonly known by the brand name, is a prescription-only medicine used to treat erectile dysfunction (ED) in adult men. It works by improving blood flow to the penis, helping to achieve and maintain an erection during sexual activity.

    Dosage and Administration

    Sildenafil is available in 25mg, 50mg, and 100mg strengths.

    • The usual starting dose is 50mg, taken approximately one hour before sexual activity.
    • Dosage can be adjusted depending on individual response and tolerability.
    • Take only one tablet in 24 hours, with or without food.
    • Avoid grapefruit juice, as it can increase the risk of side effects.
    • A high-fat meal may delay onset of action.

    Effectiveness

    Sildenafil has been shown to be effective in up to 80% of men with ED, with effects typically noticeable within 30 to 60 minutes, and lasting for up to 4–5 hours.

    Side Effects

    Common side effects include:

    • Headache
    • Flushing
    • Nasal congestion
    • Indigestion

    Less common but serious effects include visual disturbances, hearing changes, or prolonged erections. Seek medical attention if severe or persistent side effects occur.

    Contraindications

    Sildenafil should not be used by those:

    • Taking nitrates for chest pain
    • With severe heart or liver conditions
    • Under 18 years of age
    • With certain medication interactions (e.g. alpha-blockers, antifungals, antibiotics)

    Interactions

    Inform your doctor of all medications and supplements before use. Interactions may occur with:

    • Nitrates
    • Alpha-blockers
    • Some antibiotics and antifungal medicines

    Alcohol and Heart Conditions

    Avoid excessive alcohol while taking sildenafil, as it can lower blood pressure and increase side effect risk. Use with caution if you have any heart-related conditions.

    Availability and Cost

    Sildenafil is available by prescription only in the UK.

    • Generic versions are more affordable than branded Viagra.
    • Supplied by licensed UK pharmacies such as Online Chemist.
    • Avoid counterfeit products from unregulated websites.

    Take Control of Your Sex Life

    Don’t let ED affect your confidence or relationships. Buy Sildenafil tablets online today and experience more satisfying erections — securely, discreetly, and from our trusted UK-regulated pharmacy.

    ✅ Free online consultation✅ Fast UK delivery✅ Discreet packaging✅ GPhC-regulated

    now and get back to enjoying intimacy with confidence.

    Store Notice: Orders placed after 11:00 AM on Friday, 23 May 2025 will be processed on the next working day, Tuesday, 27 May 2025, due to the bank holiday weekend. Thank you for your understanding.

    Share Share

    Sildenafil citrate is available by prescription only in the UK.

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    Viagra generic entry

    The story of Viagra’s patents and generic entry of sildenafil citrate is a valuable one because it covers many of the nuances of drug patenting and generic entry in the United States.

    This article will describe the multiple patents, patent term extension, pediatric extension, litigation, out-of-court-settlement, and authorized generic fighter brand elements which led to Viagra’s long patent life and limited early entry of generics, and Pfizer’s post generic-entry strategy to limit the impact of competitors.

    Protecting Viagra with Multiple Patents and Patent Extensions

    Viagra patent 6,469,012

    was approved in 1998, and the original patent covering Viagra was, which received a 283-day patent term extension giving it an expiration date of March 29th, 2012. This 14-year patent life is longer than many other drugs, but Pfizer was able extend the patent-protected life even further.

    The ‘534 patent was filed in 1990, and in 1994 (four years prior to Viagra’s launch) Pfizer filed a second patent:. Because the ‘012 patent was filed prior to June 8th 1995 its term is17 years from the grant date, rather than20 years from the filing date, which is how expiration is determined for patents filed after Jun 8th 1995. The ‘012 patent was granted on October 22nd, 2002, so the original expiration date was set to October 22nd, 2019 — more than twenty years after the drug’s launch. The patent’s expiration was extended to April 22nd 2020 because Pfizer responded to an FDA request to perform pediatric clinical trials, granting six months of “” protection.

    Patent Challenges and Out of Court Settlement

    Pfizer v. Teva – Viagra patents

    Pfizer successfully defended Viagra’s patents in many over the years, but one lawsuit stands out. Despite prevailing in awhich affirmed the validity of patent 6,469,012, in 2013 Pfizer announced an, granting Teva a license to manufacture and sell genericstarting in December 2017, more than two years before Viagra’s patent expiration. Importantly, this was not a ‘‘ patent settlement, as Teva was required to pay Pfizer a licensing fee to produce the generic.

    Launching an Authorized Generic to Fight Generic Entry

    Revatio drug price

    Generic drugs sell at a discount to the branded version, which hurts branded revenues, but there are things which brands can do to limit the impact. A popular tactic it to launch an. In this strategy the branded firm licenses a third party to market the branded drug under another name, compelling the generic entrant (in this case Teva) to compete in the generic market. The authorized generic for Viagra was and it was.

    What About Viagra’s price?

    Viagra price trends

    Viagra’s 2016 US sales were approximately 1.2 billion, and in 2017 they dropped to less than $800 million. With increased competition from Teva and from Revatio, revenues are expected to keep dropping, and widespread generic competition from the many companies with will further-decrease Viagra sales. It appears that Pfizer is responding to increased competition by increasing Viagra’s price — the has been a general increase over time.

    Lessons for Predicting Generic Entry

    Viagra tentative approvals

    The story of Viagra and the generic entry of sildenafil citrate illustrates the value of data and the need to continuously re-evaluate factors affecting generic entry. Reliance on the first patent would have vastly under-estimated the date of generic entry, and looking solely at the expiration date of the second patent would have missed the December 2017 generic entry. DrugPatentWatch offers the tools to continuously track patents covering drugs, litigations, tentative generic approvals, and other factors essential to making better decisions. For more information, and learn more about our.

    Revatio generic entry

    Revatio is a multiple of –

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    Revatio dates the generic entry of generic drugs away significantly, but with a longer-term perspective. Inevitably, multiple patents can cause extended patent life, sometimes meaning the generic was unable to enter the market post approval.

    Note: Other medications can affect how Sildenafil is processed in your body, potentially impacting its effectiveness. These include azole antifungals (such as itraconazole or ketoconazole), macrolide antibiotics (such as clarithromycin or erythromycin), HIV protease inhibitors (such as saquinavir), mifepristone, rifampin, and ritonavir.

    Combining Sildenafil with other medications for erectile dysfunction (ED) or pulmonary hypertension, such as tadalafil or vardenafil, is harmful.

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    Sildenafil works by relaxing muscles in the blood vessels in your penis. This allows blood to flow into the penis, producing an erection during sexual stimulation.

    It’s important to note that Sildenafil will not affect testosterone. On the other hand, you may experience shortness of breath, dizziness, or a drop in blood pressure when taking Sildenafil. This is usually less dangerous but it takes men around you name your symptoms.

    If you’re using Sildenafil with a nitrates-type drug (such as nitroglycerin or isoniazid), it may cause your blood pressure to drop to a low level and you may experience chest pain or fainting. On the other hand, if you’re using Sildenafil with alpha-blockers-type drugs (such as rifampin or toenadyrowsistent), such as rifampin or toenadyrowsistent, it may cause blood to pressure to drop extremely low and you may experience dizziness or dizziness.

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    Alcohol and Sildenafil

    What are the risks of taking Sildenafil with alcohol?

    Consumption of alcohol while using Sildenafil with any of the products listed above can result in dizziness or dizziness. Avoid consuming too much or too much alcohol while using this medication.

    Remember that this medication has been prescribed for you. We will not cover this avoided with Sildenafil. However, talk to your doctor or pharmacist if you experience any specific side effects.

    Alcohol can increase the�s

    Your body may increase the side effects of this medication. These can include headaches, dizziness, or nausea. Use of this medication with Sildenafil can also result in your blood pressure rise. It’s best to avoid excessive alcohol consumption while using this medication.

    Alcohol can also affect your blood pressure. We have evaluated your medical condition, current health status, and your potential side effects, and determined that they are not life-threatening.

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